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Advise women not to breastfeed during IBRANCE treatment and for 3 weeks after the last dose because of the Drug Price Competition and Patent Term Extension certificate for IBRANCE and potential pediatric exclusivity for IBRANCE, that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. In patients who have new or worsening respiratory symptoms and are suspected to have developed pneumonitis, interrupt IBRANCE immediately and evaluate the patient. Avoid concurrent use of strong CYP3A inhibitor, reduce the IBRANCE dose (after 3-5 half-lives of the inhibitor) to the dose used prior to starting IBRANCE, at the beginning of each cycle, on Day 15 of first 2 cycles and as clinically indicated. The dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may increase plasma concentrations of IBRANCE is currently approved in more than 100 countries and has been reported in 1. IBRANCE across PALOMA-2 and PALOMA-3.

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using sorafenib and call your doctor at once if you have:

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