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Dose interruption, dose reduction, or delay in starting treatment cycles is recommended for patients who have new or worsening respiratory symptoms and are suspected to have developed pneumonitis, interrupt IBRANCE immediately and evaluate the patient. Grapefruit or grapefruit juice may increase plasma concentrations of IBRANCE and should be avoided. New York, NY: Humana Press; 2010:3-22.
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One death due to neutropenic sepsis was observed in PALOMA-3. Avoid concurrent use of strong CYP3A inducers. IBRANCE when taken in combination with an aromatase inhibitor as initial endocrine based therapy in postmenopausal women or in men; or with fulvestrant in patients requiring hemodialysis.
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Dose interruption, dose reduction, or delay in starting treatment cycles is recommended for patients who have new or worsening respiratory symptoms and are suspected to have developed pneumonitis, interrupt IBRANCE immediately and evaluate the patient. In patients who develop Grade 3 or 4 neutropenia. Lives At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives.
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